Amino
acid
Any of a class
of 20 molecules that are combined to form proteins in living things. The sequence
of amino acids in a protein, and hence protein function.
Angiogenesis
Blood vessel formation,
which usually accompanies the growth of malignant tissue.
Antibiotics
Drugs used to treat
infection.
Antibody
A protein produced
by certain white blood cells in response to a foreign substance (antigen). Each
antibody can bind only to a specific antigen.
Antigen
Any foreign or "non-self"
substance that, when introduced into the body, causes the immune system to create
an antibody.
Apoptosis
A normal cellular
process involving a genetically programmed series of events leading to the death
of a cell.
B
cells
White blood cells
that develop in the bone marrow and are the source of antibodies. Also known
as B lymphocytes.
Benign
Not cancerous; does
not invade nearby tissue or spread to other parts of the body.
Biotechnology
A set of biological
techniques developed through basic research and now applied to research and
product development.
Cancer
Diseases in which
abnormal cells divide without control. Cancer cells can invade nearby tissue
and can spread through the bloodstream and lymphatic system.
Cell
Small, watery, membrane-bound
compartment filled with chemicals; the basic unit of any living thing.
Chromosomes
Structures found in
the nucleus of a cell, which contain the genes. Chromosomes come in pairs, and
a normal human cell contains 46 chromosomes, 22 pairs
Clinical
trials
Research studies that
involve patients. Each study is designed to find better ways to prevent, detect,
diagnose, or treat disease.
Clone
A group of identical
genes, cells, or organisms derived from a single ancestor.
Differentiation
In cancer, refers
to how mature (developed) the cancer cells are in a tumour. Differentiated tumour
cells resemble normal cells and grow at a slower rate than undifferentiated
tumour.
DNA
The substance
of heredity; a linear molecule that carries the genetic information that cells
need to replicate and to produce proteins and DNA.
Drug
Any chemical compound
that may be used on humans to help in diagnosis, treatment, cure, mitigation,
or prevention of disease or other abnormal conditions.
E.
coli
Common bacterium that
has been studied intensively by geneticists because of its small genome size,
normal lack of pathogenicity, and ease of growth in the laboratory.
Enzyme
A protein that acts
as a catalyst, affecting the rate at which chemical reactions occur in cells.
Etiology
The study of the causes
of abnormal condition or disease.
False negative
When a test wrongly
shows an effect or condition to be absent (e.g., that a woman is not pregnant
when, in fact, she is).
False positive
When a test wrongly
shows an effect or condition to be present (e.g. that is woman is pregnant when,
in fact, she is not).
Gamete
Mature male or female
reproductive cell (sperm or ovum) with a haploid set of chromosomes (23 for
humans).
Gene
A unit of inheritance;
a working subunit of DNA. Each of the body's 50,000 to 100,000 genes contains
the code for a specific product, typically, a protein such as an gene's coded
information is translated into the structures present and operating in the cell
(either proteins or RNAs).
Gene
therapy
Treatment that alters
genes - the basic units of heredity found in all cells in the body.
Genetic
code
The sequence of nucleotides,
coded in triplets (codons) along the mRNA, that determines the sequence of amino
acids in protein synthesis.
Genetics
The scientific study
of heredity how particular qualities or traits are transmitted from parents
to offspring.
Genome
All the genetic material
in the chromosomes of a particular organism; its size is generally given as
its total number of base pairs.
Genotype
Genetic constitution
of an organism.
Hormones
Chemicals produced
by glands in the body and circulate in the bloodstream. Hormones control the
actions of certain cells or organs.
Immune system
The complex group
of cells and organs that defends the body against infection and disease.
In
vitro
Outside a living organism.
In
vivo
Latin phrase meaning
"in life"; in the living organism as opposed to in vitro.
Informatics
The study of the application
of computer and statistical techniques to the management of information.
Lymphatic
system
The tissues and organs,
including the bone marrow, spleen, thymus, and lymph nodes, that produce and
store cells that fight infection..
Medical device
A diagnostic or
therapeutic article that does not work by chemical action.
Metastasis
The spread of cancer
from one part of the body to another. Cells in the metastatic (secondary) tumour
are like those in the original (primary) tumour.
Mitosis
The process of nuclear
division in cells that produces daughter cells that are genetically identical
to each other and to the parent cell.
Mutation
A change in the number,
arrangement, or molecular sequence of a gene.
Nucleic
acid
A large molecule composed
of nucleotide subunits.
Nucleotide
A molecule consisting
of a nucleoside with one or more phosphate groups.
Oncogene
A unit of DNA that
normally directs cell growth, but which can also promote or allow the uncontrolled
growth of cancer if damaged (mutated) by an environmental exposure to carcinogens
Organelle
A discrete subcellular
structure that has a specialised function (eg, nucleus, mitochondrion).
Peptide
A molecule consisting
of 2 to approximately 20 amino acids connected by peptide bonds; a short segment
of a larger protein or a completely functional molecule unto itself.
pH
"Potency
of hydrogen"; a measure of acidity or alkalinity.
Phenotype
Observable characteristics
of an organism produced by the organism's genotype interacting with the environment.
Plasmid
Autonomously replicating,
extrachromosomal circular DNA molecules, distinct from the normal bacterial
genome and nonessential for cell survival.
Protein
A large, complex molecule
composed of amino acids.
Receptor
A protein or group
of associated proteins in a cell or on its surface that selectively binds a
specific substance (called a ligand).
Recessive
A gene that is phenotypically
manifest in the homozygous state but is masked in the heterozygote by the presence
of a dominant allele.
Recombination
The natural process
of breaking and rejoining DNA strands to produce new combinations of genes and,
thus, generate genetic variation.
Red
blood cells
Cells that carry oxygen
to all parts of the body. Also called erythrocytes.
RNA
A chemical found in
the nucleus and cytoplasm of cells; it plays an important role in protein synthesis
and other chemical activities of the cells from which all blood cells develop.
T
cell
White blood cell critical
to the immune response.
Telomere
The ends of chromosomes.
These specialized structures are involved in the replication and stability of
linear DNA molecules. See DNA replication.
Transcription
The process of copying
information from DNA into new strands of messenger RNA (mRNA).
Transfer
RNA
A class of RNA having
structures with triplet nucleotide sequences that are complementary to the triplet
nucleotide coding sequences of mRNA.
Translation
The process of turning
instructions from mRNA, base by base, into chains of amino acids that then fold
into proteins.
Tumor
necrosis factor
A type of biological
response modifier (a substance that can improve the body's natural response
to disease).
Tumor
suppressor gene
Genes that normally
restrain cell growth but, when missing or inactivated by mutation, allow cells
to grow uncontrolled.
Vector
A self-replicating
DNA molecule that transfers a DNA segment between host cells.
White
blood cells
Cells that help the
body fight infection and disease.