Research Associate in Advanced Cryo-Imaging (Maternity Cover 12 Months) 10387
Rosalind Franklin Institute
As a Research Associate at the Franklin, you will bring scientific knowledge and skills to deliver a specific research project and/or you will bring independent, creative science, or specific skills to a team delivering a project or program. Through this work, you will build scientific independence, develop new science and leadership skills, and establish a growing reputation externally.
The successful candidate will exploit advanced cryogenic correlative imaging approaches to dissect the molecular, structural, and biophysical mechanisms governing HIV maturation and early entry. In collaboration with the group of Sergi Padilla at Kings College, you will combine time-resolved FLIM/FRET measurements employing custom-engineered biosensors with cryo-electron tomography and high-resolution structural analysis to resolve dynamic conformational and assembly processes during viral maturation, thereby delivering new mechanistic insights into HIV infectivity. The direction of the project will be to push this nascent correlative technique into the cell, potentially into tissues, to enable lifetime-based correlation of features within the cell.