Iksuda Therapeutics Ltd

Iksuda Therapeutics (Iksuda), is a developer of a new generation of antibody drug conjugates (ADCs) leveraging the improved safety profile of tumour activated payloads and raising the therapeutic index for the treatment of difficult to treat haematological and solid tumours.

About Iksuda Therapeutics: www.iksuda.com Iksuda Therapeutics is a UK-based biotechnology company focussed on the development of a new generation antibody drug conjugates (ADCs) targeting difficult-to-treat haematological and solid tumours. Iksuda’s pipeline of ADCs is centred on a portfolio of non-prodrug/prodrug DNA and protein alkylating payloads in combination with stable conjugation chemistries including its proprietary PermaLink® platform. The Company’s ADCs portfolio is designed to significantly improve the therapeutic index of this important modality and improve the outcomes for patients living with cancer. About IKS014 IKS014 is a potential best-in-class HER2-targeting ADC. In preclinical trials, it displayed impressive activity in high- and low-HER2 expressing tumours with significantly higher HNSTD vs other HER2-directed drugs. A phase 1a clinical trial is nearing completion in China, with phase1b in HER2-positive breast cancer patients planned to start soon. Phase 2 trials in HER2-positive gastric cancer patients are planned for 2022. About IKS03 IKS03 is a best-in-class CD19-targeting ADC delivering a tumour-activated prodrug pyrrolobenzodiazepine (PBD) which was licensed from LegoChem Biosciences (https://iksuda.com/2020/05/licensing-agreement-with-legochem-biosciences/). Preclinical testing demonstrates best-in-class efficacy (vs in-clinic and marketed CD19-targeted therapies) in in vivo xenograft models and significantly raised maximum tolerated dose (MTD) in non-human primate disease models, demonstrating its potential to be the leading anti-CD19 therapy in B-cell cancers. IND is planned for Q2 2022, with initial phase 1 patient data anticipated Q3 2022.

• Platform Technology
• Oncology