Deadline: 3 December 2025

Longitude Prize on ALS

The £7.5 million Longitude Prize on ALS is an international challenge prize to incentivize the use of AI-based approaches to transform drug discovery for the treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neurone disease (MND).

The prize opened for entries on 25th June 2025, and will initially offer 20 entrants the chance to win £100k ‘Discovery Awards’, with those who are successful finding out in the first half of 2026.

The Longitude Prize on ALS is principally funded by the MND Association and designed and delivered by Challenge Works, supported by Nesta. Additional funders include Nesta, the Alan Davidson Foundation, My Name’5 Doddie Foundation, LifeArc, FightMND, The 10,000 Brains Project, Answer ALS and The Packard Center at Johns Hopkins University.

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