Feasibility Without Guesswork: Unlocking Genomic and Real-World Data for Faster Study Execution

Clinical trial feasibility has long been constrained by the same fundamental problem: the data used to estimate patient availability rarely reflects the patients who will actually enroll. Site surveys capture what investigators think they have seen. Historical enrollment figures describe what happened in prior studies under different protocols. Neither answers the question that matters: do the right patients, with the right biology, exist at the right sites today?

This webinar introduces a new feasibility standard — one grounded in connected real-world evidence that spans structured clinical data, genomic and biomarker profiles, and unstructured clinical notes. Together, these data layers allow sponsors and clinical operations teams to test protocol feasibility before sites are selected, not after activation has already committed resources to the wrong locations.

Samantha Eells, Solutions and Market Lead for Clinical Operations at TriNetX, and Mark Hughes, Genomics Solution Engineer at TriNetX, will walk attendees through how deeper, more connected data transforms each stage of the feasibility process. Attendees will learn how to translate complex protocol eligibility criteria — including molecularly defined inclusion requirements — into queryable variables across real-world patient populations, how to identify sites where both the patient population and the operational evidence support successful enrollment, and why combining structured EHR data with genomic profiles and clinical notes produces fundamentally more reliable feasibility estimates than any single data type alone.

For precision medicine studies, oncology trials, and rare disease programs in particular, ICD and CPT codes alone cannot define the eligible population. A patient with the right diagnosis may lack the required biomarker. A site with high volume may have no genomic data coverage. This webinar addresses both gaps — and demonstrates how connecting these evidence layers earlier in study design reduces the risk of missed enrollment targets, delayed timelines, and costly protocol amendments.
Attendees will leave with a practical framework for evidence-driven feasibility and a clearer picture of what it means to select sites based on confidence, not assumption.

Who Should Attend
This webinar will appeal to:

• Clinical Operations leaders
• Clinical Trial Managers
• Clinical Feasibility Managers
• Clinical Study Leads
• Site Selection & Patient Recruitment teams
• Biostatistics & Data Science leaders
• Medical Affairs professionals
• Clinical Development leaders
• Translational Medicine teams
• CRO leaders supporting feasibility and study startup
• Precision Medicine and Genomics Program leaders

What You Will Learn
Attendees will gain insight into:

• Traditional feasibility tools overestimate patient availability — real-world data connected to actual protocol criteria produces more reliable site selection
• Genomic and biomarker data enables molecularly defined eligibility assessment that ICD/CPT codes alone cannot support
• Clinical notes unlock eligibility signals hidden in unstructured text, reducing both false positives and missed patients
• Connecting clinical, genomic, and notes data into a single feasibility workflow gives sponsors higher-confidence site prioritisation earlier in study design

Register free on Xtalks:
https://xtalks.com/webinars/feasibility-without-guesswork-unlocking-genomic-and-real-world-data-for-faster-study-execution/