Sitryx Therapeutics Ltd

Sitryx is a biopharmaceutical company focused on regulating cell metabolism to develop disease modifying therapeutics in immuno-oncology and immuno-inflammation.

The energetic status of cells has been shown to be pivotal in controlling the behaviour of disease associated cells in immuno-oncology and immuno-inflammation. Correcting immune cell function and/or inhibiting tumour cell growth through targeting metabolic pathways has the potential to deliver new complimentary and highly differentiated approaches to treat a wide range of severe diseases. Sitryx's proprietary science is led by a highly experienced management team, supported by GSK's drug discovery experience and world class academic founders. Sitryx was founded by six world leading researchers in the field of immunology and immuno-regulation including Houman Ashrafian, Luke O'Neill, Jonathan Powell, Jeff Rathmell, Michael Rosenblaum and Paul Peter Tak. Together they have published more than 1,000 papers in the field, making multiple key breakthroughs in our understanding of how critical energetic status is to the behaviour of immune cells in the broader field of immunology. Sitryx was founded in 2018 with seed funding from SV Health Investors and raised USD30m Series A funding from an international syndicate of specialist investors including SV Health Investors, Sofinnova Partners, Longwood Fund and GSK. The company has a pipeline of projects at multiple stages of drug discovery. Sitryx is headquartered in Oxford.

• Small molecules
• Immunology/inflammation
• Autoimmune diseases
• Oncology