XenoGesis supports Sitryx in the Discovery and Development of Immunometabolic Medicines

Nottingham-based leading DMPK provider, XenoGesis, has been working with biopharmaceutical company Sitryx to support the discovery of novel targets and the development of innovative therapies for autoimmune and inflammatory disease in the fast-emerging area of immunometabolism.

Sitryx turned to XenoGesis for its scientific expertise and influence in solving the complex PK problems in their multiple projects and helping drive forward their PK-PD efforts to discover potential new medicines for autoimmune diseases.

Graham Trevitt, Chief Scientific Officer at XenoGesis, commented: “We have been working with the team at Sitryx since the end of 2019. Sitryx came to us because of our expertise in solving complex PK challenges as well as our focus on generating and using high quality data. We have worked closely with them as an extension of their team, and look forward to a long and collaborative relationship.”

Matthew Fyfe, Head of Chemistry and Intellectual Property at Sitryx commented: “We have been seriously impressed by XenoGesis’ enthusiasm and professionalism with this project. With their help and expertise, we believe we can move forward and deliver cutting-edge, disease modifying immunometabolism therapeutics that can transform the lives of patients with serious autoimmune disorders.”

He continued: “The team at XenoGesis has dramatically transformed our thinking around in vitro and in vivo DMPK data over the past few months. We look forward to continuing to work with XenoGesis to achieve that aim in the coming years.”

Sitryx recently announced a licensing and research collaboration with Eli Lilly, to discover and develop new immune-metabolic medicines, in a transformational collaboration enabling the company to bolster its research endeavours over the next five years. Under the terms of the agreement, Sitryx will receive an upfront payment of $50 million and Lilly will make a $10 million equity investment in Sitryx. Sitryx will be eligible to receive potential development milestones up to $820 million, as well as commercialisation milestones and royalty payments on potential sales in the mid- to high-single digit range.

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For more information, contact:

Sue Carr, Marketing & Communications, on 07809 727533 or [email protected]

About XenoGesis Ltd

XenoGesis Ltd. specialises in preclinical drug metabolism and pharmacokinetics (DMPK), quantitative bioanalysis, in vitro pharmacology and modelling and simulation for human PK and dose prediction. The core XenoGesis team has a proven track record of delivery in drug discovery. Through a consultative approach, the XenoGesis team helps to identify the potential ‘winners’ and ‘losers’ in a selection of compounds synthesised in drug discovery campaigns, providing significant time and cost savings for R&D companies. Moreover, providing iterative feedback to the research team based on the results and recommending next steps is a key focus for XenoGesis. The organisation combines its state-of-the-art in vitro, in vivo and bioanalytical capabilities with its expert pharmacokinetic/ pharmacodynamic (PK/PD) data interpretation services with GastroPlus™. Their laboratory tests build a full picture of the ADME properties of a molecule including required human drug exposure, backed-up with advice on how to modify the chemical structure of a compound to make it more ‘drug-like’. This unique offering is what make the XenoGesis service attractive to global drug companies.

XenoGesis is a laboratory-based contract research organisation (CRO) based at BioCity in Nottingham and its Founder and CEO is Dr Richard Weaver FRSC.

For more information, visit www.xenogesis.com and follow on Twitter @XenoGesis

About Sitryx

Sitryx is a biopharmaceutical company focused on regulating cell metabolism to develop disease-modifying therapeutics in immuno-oncology and immuno-inflammation. Sitryx’s proprietary science is led by a highly experienced management team and supported by world-class academic founders. Sitryx was founded by six world-leading researchers in the field of immunology and metabolisim; Housman Ashrafian, Luke O’Neill, Jonathan Powell, Jeff Rathmell, Michael Rosenblum and Paul Peter Tak. Together they have published more than 1,000 papers in the field, making multiple key breakthroughs in our understanding of how critical energetic status is to the behaviour of immune cells and in the broader field of immunology. Sitryx is headquartered in Oxford, UK. For more information, visit www.sitryx.com