In vivo
CAR-T therapy requires durable, yet transient CAR expression coupled with efficient, T cell-specific delivery. This webinar will focus on how innovations in RNA design and next-generation lipid nanoparticle (LNP) technology are enabling direct
in vivo
engineering of T cells, replacing conventional
ex vivo
manufacturing. This webinar will explore key advances in CAR construct design and novel LNP formulations to improve the precision, potency and safety of
in vivo
CAR-T therapies.
Modular “drop-in” CAR plasmids that streamline both construct design and RNA production will be introduced. These vectors produce mRNAs optimized for CAR expression and support flexible swapping of antigen-binding domains, enabling rapid screening and efficient customization. This approach may be particularly useful for researchers who are new to CAR-T development.
The featured speaker will present recent innovations in RNA design to enhance expression, durability and tissue specificity. These innovations include a modified poly(A) tail that improves transcript stability and translational efficiency and a T cell-specific internal ribosome entry site (IRES) that, when incorporated into circular RNA (circRNA), restricts CAR expression to T cells and reduces off-target effects.
This session will also highlight novel LNP technology engineered for T cell-directed delivery, including exosome-like and spleen-tropic LNPs that enrich delivery to lymphoid tissues where T cells are concentrated and improve CAR expression. VHH site-specific conjugated LNPs that employ single-domain antibody fragments for precise T cell targeting will also be discussed. Collectively, these advances in CAR construct design, RNA engineering and targeted LNP systems represent a comprehensive toolbox for next-generation
in vivo
CAR-T therapy development.
Register for this webinar to learn how LNP technology can support targeted RNA delivery and
in vivo
CAR-T cell engineering.
Who Should Attend
This webinar will appeal to scientists seeking broader knowledge of CAR-T technologies and researchers working in:
Novice and advanced CAR-T therapy development
mRNA and circRNA design
LNP formulation and targeted LNP development
Non-viral delivery
What You Will Learn
Attendees will:
Gain an understanding of the concepts of CAR-T therapy and how LNP delivery of mRNA can be used for
in vivo
CAR-T cell engineering
Discover how recent innovations in mRNA design and LNP formulations enable in vivo CAR-T development
Learn how to apply the latest in
in vivo
CAR-T technology to research and clinical programs
Register free on Xtalks:
https://xtalks.com/webinars/advances-in-mrna-lnp-technology-for-in-vivo-car-t-therapy/
