Therapeutic antibodies are a rapidly growing class of drugs. Their application areas are not only limited to the standard immunoglobulin G (IgG) format but can also be extended to novel formats, including antibody fragments (scFv, VHH), drug conjugates and bispecifics. This webinar explores platform selection and development strategies for generating high-performance anti-idiotype (anti-ID) antibodies to support pharmacokinetic (PK) and anti-drug antibody (ADA) assays.
To ensure their safety and efficacy, regulatory agencies and pharmaceutical developers rely on two essential types of assays: PK assays and ADA assays. PK measures how a drug is absorbed, distributed, metabolized and eliminated in the body. ADA assays are designed to detect and measure the immunogenicity of an antibody drug after treatment.
Anti-ID antibodies bind to the idiotype, a specific epitope group on the variable region, of another antibody, usually an antibody drug. High-performance anti-IDs are critical for developing sensitive, specific and robust PK and ADA assays to support pre-clinical and clinical studies in drug development programs. High sensitivity and specificity, strong affinity and well-defined epitope-binding specificity are important features for anti-IDs.
Rabbit monoclonal antibodies (mAbs) are known for their high affinity and diversity, making them a valuable source of highly specialized research reagents. The lower homology of the antibody drug to rabbit germline sequences compared with mice suggests that rabbits may generally mount a stronger immune response to an antibody drug than mice. An optimized rabbit B cell cloning platform can support the discovery of high-quality anti-IDs with high sequence diversity and affinity, including blocker and non-blocker antibodies.
Register for this webinar to learn how anti-idiotype antibody development strategies can support sensitive, specific PK and ADA assays.
Who Should Attend
This webinar will appeal to professionals working in:
Pharmacokinetics
Immunogenicity and ADA Assay Development
Antibody Drug Discovery
Cell and Gene Therapy
Pharma/biotech conducting late pre-clinical studies/clinical studies
What You Will Learn
Attendee will gain insight into:
Why anti-IDs fail and the downstream impact on PK and ADA programs
How to select the optimal anti-ID discovery platform and strategy for an antibody drug target
How blocker and non-blocker anti-IDs can be generated and evaluated through case studies
Register free on Xtalks:
https://xtalks.com/webinars/platform-selection-and-development-strategies-for-high-performance-anti-idiotype-antibody-development-in-just-9-weeks/
